- Eames, Frederick W. - American patentee of a vacuum brake system and founder of Eames Vacuum Brake Company. (White 1973)
- Eastman, Joseph B. - Director of the US Office of Defense Transportation. (Palmer 1942)
- Eaton, Cyrus S. (1883-1979) - President of Chesapeake & Ohio Railway, instrumental in forming the merger that became Chessie System in the early 1970s.
- Edson, Job A. (1854-1928) - President of Kansas City Southern Railway 1905-1918 and 1920-1927.
- Elliott, Howard (1860-1928) - President of Northern Pacific Railway 1903-1913; president of New York, New Haven & Hartford Railroad 1913-.
- Ellis, Ed - President of Iowa Pacific Holdings -present.
- Engerth, Wilhelm (1814-1884) - Austrian architect and engineer who designed the first practical mountain locomotive.
- Evans, Oliver (1755-1819) - Steam locomotive designer and inventor.
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