- Cable, Ransom Reed - Chicago, Rock Island & Pacific Railroad 1883-1898.
- Cahill, Michael Harrison - Missouri-Kansas-Texas Railroad 1930-1933.
- Cail, Jean-François (1804-1871) - French steam locomotive builder and licensee of the Crampton type locomotive in France.
- Calhoun, Patrick (1856-1943) - United Railroads of San Francisco.
- Calthorp, Everard (1857-1927) - British railway engineer, promoter and builder of narrow gauge railways; founded the Barsi Light Railway in 1895; served as a consultant for a number of narrow gauge railways around the world.
- Calthorp, Guy (1870-1919) - Began railroad career with the London & North Western Railway in 1886; General Superintendent of Caledonian Railway 1902-1908, General Manager of same 1908-1910; General Manager of Buenos Aires & Pacific Railway 1910-1913; General Manager of London & North Western Railway 1914-1919.
- Calvin, E. E. - Union Pacific Railroad 1916-1918.
- Campbell, Henry R. (1807-1879) - Patentee of the 4-4-0 locomotive.
- Campbell, James - Chairman of the Board for Alaska Railroad 1984-__.
- Campbell, John Williams (1880-1957) - Director for New York Central Railroad 1920-__; chairman of the board for Hudson & Manhattan Railroad __-1957.
- Carper, Thomas C. - Chairman of the Board for Amtrak -present.
- Carroll, Charles of Carrollton (1737-1832) - Helped with founding the Baltimore & Ohio Railroad; laid the cornerstone at the beginning of construction in 1828.
- Carter, Thomas S. - Kansas City Southern Railway 1973-.
- Carver, Hartwell (1789-1875) - Promoter of a railroad line across the United States to the Pacific coast as early as 1832; participated in hammering the Golden Spike at Promontory, Utah, in 1869.
- Casement, John S. (1829-1909) - Directed construction of the First Transcontinental Railroad as Chief Engineer for Union Pacific Railroad beginning in 1866.
- Casey, Samuel B., Jr. (1927-2006) - CEO and President of Pullman Company 1970-1980.
- Cass, George Washington (1810–1888) - Pennsylvania Railroad; Northern Pacific Railway 1872-1875.
- Cassatt, Alexander (1839-1906) - Brother of American painter Mary Cassatt. President of Pennsylvania Railroad 1899–1906.
- Cavanaugh, Dennis Miles - Soo Line Railroad 1983–1986, 1987–1989.
- Celinski, Krzysztof - Polskie Koleje Państwowe 2005-present.
- Chalmers, W. - Chief Mechanical Engineer for North British Railway 1919-1922.
- Chanute, Octave (1832-1910) - Designed the Hannibal Bridge, the first railroad bridge across the Missouri River in 1869; invented the process of pressure treating ties with creosote to preserve them.
- Chapelon, André (1892-1978) - French steam locomotive designer.
- Chapin, Chester William (1798-1883) - President of Western Railroad Corporation 1854-1867; president of Boston & Albany Railroad 1868-1878
- Charlick, Oliver - Long Island Rail Road 1863-1875.
- Chatfield, Levi S. (1808-1884) - Major stockholder of Atlantic & Pacific Railroad 1853-1854.
- Chipley, William Dudley (1840-1897) - Columbus & Rome Railroad; Baltimore & Ohio Railroad 1873-1876; Pensacola & Atlantic Railroad.
- Christy, Doug - Iowa Interstate Railroad.
- Chrysler, Walter (1875-1940) - Worked as a mechanic for various railroads including the Fort Worth & Denver Railway; Manager of ALCO's Allegheny erecting shops until 1911.
- Churchward, George Jackson (1857-1933) - Chief Mechanical Engineer of Great Western Railway 1902-1922.
- Clapp, Harold Winthrop (1875-1852) - Began railroad career with the Brisbane Tramway Company. Moved to the US in 1900, eventually finding work on the Interborough Rapid Transit Company in New York. He was in charge of the electrification of the Pennsylvania Railroad's West Jersey and Seashore Divisions. He then moved to Ohio in 1908 and joined the Southern Pacific Railroad where he worked his way up to become a vice president. He also worked during this time for the Columbus Railway Power & Light Company and the East St. Louis Suburban Railway. He returned to Australia in 1920 when he was named Chairman of the Commissioners of Victorian Railways. He was appointed Director-General of Land Transport in 1942; while in this position in 1944, he submitted a plan to convert all existing rail lines in Australia to standard gauge. He retired in 1951.
- Clark, D. K. - Chief Mechanical Engineer for Great North of Scotland Railway 1853-1855.
- Clark, Horace F. (1815-1873) - Union Pacific Railroad 1872-1873.
- Clark, John P. - New York, Susquehanna & Western Railway.
- Clark, S. H. H. - Union Pacific Railroad 1892-1898.
- Clarke, F. B. - Spokane, Portland & Seattle Railway 1907-.
- Claytor, Robert B. (1922-1993) - Norfolk & Western Railway 1981-1982; Norfolk Southern Railway 1982-1993.
- Claytor, W. Graham, Jr. (1912-1994) - President of Southern Railway 1967-1976, chairman of Southern Railway 1976-1977; during his tenure at Southern Railway, he oversaw creation of the railroad's heritage steam operations program, a program that was continued by successor Norfolk Southern. President of Amtrak 1982-1993. (Scull, June 1991, p 24. Phillips, June 1991, p 28)
- Clegg, Charles M., Jr. (1916-1979) - Author, photographer and railroad historian.
- Clement, Martin W. (1881-1966) - Pennsylvania Railroad 1935–1948.
- Coffin, Lorenzo S. (1823-1915) - Railroad safety advocate.
- Coe, William R. (1869-1955) - Virginian Railway.
- Colburn, Zerah (1832-1870) - Apprentice in the drafting room at Lowell Machine Shops; worked for most of the locomotive builders in New Jersey; hired by American Railroad Journal in 1853; split off to start his own railroad journal, Railroad Advocate, but was forced to close it in 1857; moved to London to become editor of The Engineer in 1858; founded Engineering in 1866 as a competitor to The Engineer.
- Cole, Francis J. (1856-1923) - Locomotive designer.
- Coleman, D'Alton Cory - Canadian Pacific Railway 1942-1947.
- Coleman, William C. (1901-1976) - President of Monon Railroad. (Railway Age, August 9, 1976, p 43)
- Coliton, William P. - Chicago South Shore & South Bend Railroad 1961-.
- Colket, Coffin - Long Island Rail Road 1862-1863.
- Collins, David J. - Buffalo & Pittsburgh Railroad -present.
- Colnon, Aaron - Chicago, Rock Island & Pacific Railroad 1942-1947.
- Connor, Benjamin - Locomotive Superintendent for Caledonian Railway 1856-1876.
- Conti, P. Scott - Providence & Worcester Railroad 2005-present.
- Cooke, Bates (1787-1841) - Controlling partner of the Lewiston Railroad in New York.
- Cooke, Jay (1821-1905) - Founder of Jay Cooke & Co. bank; president and chief financier of Northern Pacific Railway 1870-1873. The failure of Jay Cooke & Co. in 1873 due to overextended railroad investments led to the great financial panic of 1873.
- Cooke, John (1824-1882) - Apprenticed to Thomas Rogers to learn locomotive manufacturing; shop superintendent for Rogers Locomotive & Machine Works 1843-1852; partnered with Charles Danforth to form Danforth, Cooke & Co.
- Cooley, Thomas M. (1824-1898) - First chairman of the Interstate Commerce Commission.
- Coolidge, T. Jefferson (1831-1920) - President of Atchison, Topeka & Santa Fe Railway 1880–1881, succeeded by William B. Strong.
- Corbin, Austin (1827-1896) - President of Long Island Rail Road 1881-1896.
- Corning, Erastus (1794-1872) - Utica & Schenectady Railroad 1830s-1853; New York Central Railroad 1853-1865.
- Côté, Paul - President of VIA Rail 2005-present.
- Cotton, Edward John (1829-1899) - Clerk for the Railway Clearing House 1847-1851; hired by North Eastern Railway as a Railway Clearing House trainer; Manager of Waterford & Kilkenny Railway 1853-1857; Traffic Manager of Belfast & Balleymena Railway 1857-1860; continued with Belfast & Northern Counties Railway; Manager of Ballymena, Cushendall & Red Bay Railway 1875-1884.
- Couch, C. P. "Pete" (1890-1955) - Brother of Harvey C. Couch. President of Kansas City Southern Railway 1939-1941.
- Couch, Harvey C. (1877-1941) - Brother of C. P. Crouch. Led an investment consortium to control the Louisiana & Arkansas Railway in 1928; president of Kansas City Southern Railway 1939; oversaw KCS's purchase of L&A then turned over the KCS presidency to his brother.
- Cowan, W. - Chief Mechanical Engineer for Great North of Scotland Railway 1857-1883.
- Crampton, Thomas (1816-1888) - English steam locomotive builder; namesake of the Crampton locomotive type.
- Crane, L. Stanley - Southern Railway 1977-1980.
- Crerar, Peter (1785-1856) - Designed the Albion Mines Railway (the first railway in British North America) in 1836.
- Cret, Paul Philippe (1876-1945) - Architect and industrial designer; design consultant for Cincinnati Union Terminal; designed the side fluting on the Pioneer Zephyr trainset (which debuted in 1934) and on the Santa Fe's Super Chief passenger cars (debuted in 1936).
- Crocker, Charles (1822-1888) - A member of the Big Four group of financiers in California; president of Central Pacific Railroad.
- Crosbie, William - Acting President of Amtrak 2008.
- Crozet, Claudius (1789-1864) - Principal Engineer and Surveyor for the Virginia Board of Public Works 1823-1832 and 1837-1843 where he worked on a number of railroad related projects including the design of the Chesterfield Railroad.
- Crump, Norris Ray "Buck" (1904-1989) - Canadian Pacific Railway 1955-1964 and 1966.
- Crush, William George - General passenger agent for Missouri-Kansas-Texas Railroad who staged the "Crash at Crush" publicity stunt in 1896.
- Culver, Andrew - Prospect Park & Coney Island Railroad.
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